Vitamin D and multiple sclerosis hospital admissions in Scotland.
نویسندگان
چکیده
G. DISANTO, A.E. HANDEL, J.M. MORAHAN, G.C. DELUCA, S.M. KIMBALL, E. HYPPONEN, G. GIOVANNONI, G.C. EBERS and S.V. RAMAGOPALAN From the Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK, Nuffield Department of Clinical Neurosciences (Clinical Neurology), University of Oxford, The West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK, Centre for Paediatric Epidemiology and Biostatistics and MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London WC1N 1EH, UK, Blizard Institute, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, E1 2AT, UK
منابع مشابه
The Epidemiology of Multiple Sclerosis in Scotland: Inferences from Hospital Admissions
BACKGROUND Multiple sclerosis (MS) is a neurological disorder with a highly characteristic disease distribution. Prevalence and incidence in general increase with increasing distance from the equator. Similarly the female to male sex ratio increases with increasing latitude. Multiple possible risk factors have been hypothesised for this epidemiological trend, including human leukocyte antigen a...
متن کاملO 1: The Effects of Vitamin D Supplementation on the T cell Compartment in Multiple Sclerosis
Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...
متن کاملEffect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis
Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
متن کاملThe Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients
Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...
متن کاملP98: Vitamin-D Deficiency as a Potential Risk Factor in Multiple Sclerosis
Multiple sclerosis (MS) is a multifactorial disorder caused by the effects of several genes in combination with environmental factors. This disease is characterized by myelin loss, varying degrees of axonal pathology and inflammatory lesions. It is an important cause of disability in young adults, seen to be more prevalent in the woman, and affects 2.5 million people worldwide. Great efforts ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- QJM : monthly journal of the Association of Physicians
دوره 104 11 شماره
صفحات -
تاریخ انتشار 2011